Safety of anti-TNF- therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis

Safety of anti-TNF-alpha therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis.

OBJECTIVE To assess the safety of anti-tumour necrosis factor (TNF)-alpha therapy in patients with rheumatoid arthritis (RA) or spondylarthropathies (SA) and concurrent chronic hepatitis B or C. METHODS Records concerning 480 outpatients attending the Rheumatology Department of the University Hospital of Nice (France) for RA or SA were retrospectively reviewed for the duration of disease, tre...

Safety of anti-TNF-a therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis

Objective. To assess the safety of anti-tumour necrosis factor (TNF)-a therapy in patients with rheumatoid arthritis (RA) or spondylarthropathies (SA) and concurrent chronic hepatitis B or C. Methods. Records concerning 480 outpatients attending the Rheumatology Department of the University Hospital of Nice (France) for RA or SA were retrospectively reviewed for the duration of disease, treatme...

The safety of anti-TNF therapy in patients with hepatitis B and C virus infection

Anti-TNF-directed therapies were introduced into clinical practice almost 15 years ago, heralding a new era in the treatment of various autoimmune or autoinf lammatory diseases, such as rheumatoid arthritis (RA), spondyloarthropathies (ankylosing spondylitis and psoriatic arthritis), psoriasis and inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) [1]. This era – now referred ...

safety of anti-tnf-α therapy in patients with psoriasis and concomitant hepatitis c virus infection

O4: Central Nervous System Involvement in Rheumatoid Arthritis: Possible Role of Chronic Inflammation and TNF Blocker Therapy

Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. In recent years, the pathophysiology of CNS involvement that can occur in RA has attracted a great deal of attention. Emphasis has focused on the possibility that CNS involvement occurs due to bl...